The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a and α mating-type informati...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Kaeberlein, Matt, McVey, Mitch, Guarente, Leonard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 1999
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10521401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.19.2570
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