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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

There is growing evidence that the p53 tumor suppressor protein not only can function to activate gene transcription but also to repress the expression of specific genes. Although recent studies have implicated the transcriptional repression function of p53 in the pathway of apoptosis, the molecular...

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Main Authors: Murphy, Maureen, Ahn, Jaimo, Walker, Kristen K., Hoffman, William H., Evans, Ronald M., Levine, Arnold J., George, Donna L.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1999
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC317076/
https://ncbi.nlm.nih.gov/pubmed/10521394
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