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Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, Stat3 is specifically activated. To address the function of this signaling molecule in mammary epithelial apoptosis, we have generated a conditional knockout of Stat3 using the Cre-l...

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Published in:Genes Dev
Main Authors: Chapman, Rachel S., Lourenco, Paula C., Tonner, Elizabeth, Flint, David J., Selbert, Stefan, Takeda, Kiyoshi, Akira, Shizuo, Clarke, Alan R., Watson, Christine J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317074/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10521404/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.19.2604
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