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Enhancer control of V(D)J recombination at the TCRβ locus: differential effects on DNA cleavage and joining
Deletion of the TCRβ transcriptional enhancer (Eβ) results in nearly complete inhibition of V(D)J recombination at the TCRβ locus and a block in αβ T cell development. This result, along with previous work from many laboratories, has led to the hypothesis that transcriptional enhancers affect V(D)J...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC317053/ https://ncbi.nlm.nih.gov/pubmed/9694796 |
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