CLSM as Quantitative Method to Determine the Size of Drug Crystals in a Solid Dispersion

PURPOSE: To test whether confocal laser scanning microscopy (CLSM) can be used as an analytical tool to determine the drug crystal size in a powder mixture or a crystalline solid dispersion. METHODS: Crystals of the autofluorescent drug dipyridamole were incorporated in a matrix of crystalline manni...

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Autors principals: de Waard, Hans, Hessels, Martin J. T., Boon, Maarten, Sjollema, Klaas A., Hinrichs, Wouter L. J., Eissens, Anko C., Frijlink, Henderik W.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170464/
https://ncbi.nlm.nih.gov/pubmed/21607777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0484-8
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