Igf2 imprinting does not require its own DNA methylation or H19 RNA

Three models have been proposed to explain the imprinting of the mouse Igf2 gene on the maternal chromosome. We ruled out the importance of DNA methylation at Igf2 by showing that silencing of Igf2 accompanying the loss of DNA methylation could be overcome by a mutation at the neighboring H19 gene t...

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Bibliographic Details
Main Authors: Jones, Beverly K., Levorse, John M., Tilghman, Shirley M.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC317014/
https://ncbi.nlm.nih.gov/pubmed/9679064
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