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Conformational selection or induced fit? 50 years of debate resolved

Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates “allosteric” interactions between regulatory sites and biologically active sites in regulatory/receptor proteins. Do the different conformations involved already exist spontaneously in t...

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Detalhes bibliográficos
Main Authors: Changeux, Jean-Pierre, Edelstein, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: Faculty of 1000 Ltd 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169905/
https://ncbi.nlm.nih.gov/pubmed/21941598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3410/B3-19
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