A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

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Bibliografiske detaljer
Main Authors: Nicholson, George, Rantalainen, Mattias, Li, Jia V., Maher, Anthony D., Malmodin, Daniel, Ahmadi, Kourosh R., Faber, Johan H., Barrett, Amy, Min, Josine L., Rayner, N. William, Toft, Henrik, Krestyaninova, Maria, Viksna, Juris, Neogi, Sudeshna Guha, Dumas, Marc-Emmanuel, Sarkans, Ugis, Donnelly, Peter, Illig, Thomas, Adamski, Jerzy, Suhre, Karsten, Allen, Maxine, Zondervan, Krina T., Spector, Tim D., Nicholson, Jeremy K., Lindon, John C., Baunsgaard, Dorrit, Holmes, Elaine, McCarthy, Mark I., Holmes, Chris C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169529/
https://ncbi.nlm.nih.gov/pubmed/21931564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002270
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