A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

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Hauptverfasser: Nicholson, George, Rantalainen, Mattias, Li, Jia V., Maher, Anthony D., Malmodin, Daniel, Ahmadi, Kourosh R., Faber, Johan H., Barrett, Amy, Min, Josine L., Rayner, N. William, Toft, Henrik, Krestyaninova, Maria, Viksna, Juris, Neogi, Sudeshna Guha, Dumas, Marc-Emmanuel, Sarkans, Ugis, Donnelly, Peter, Illig, Thomas, Adamski, Jerzy, Suhre, Karsten, Allen, Maxine, Zondervan, Krina T., Spector, Tim D., Nicholson, Jeremy K., Lindon, John C., Baunsgaard, Dorrit, Holmes, Elaine, McCarthy, Mark I., Holmes, Chris C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169529/
https://ncbi.nlm.nih.gov/pubmed/21931564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002270
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