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NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

The proinflammatory and catabolic cytokine IL-1β has been implicated in the pathogenesis of osteoarthritis (OA) by mediating synovial inflammation and cartilage degeneration. Although synovial macrophages are suggested to be the source of IL-1β, the mechanism remains unclear. Ectopic deposition of h...

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Detalhes bibliográficos
Main Authors: Jin, Chengcheng, Frayssinet, Patrick, Pelker, Richard, Cwirka, Diane, Hu, Bo, Vignery, Agnès, Eisenbarth, Stephanie C., Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169126/
https://ncbi.nlm.nih.gov/pubmed/21856950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111101108
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