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A cell-based high-throughput screen to identify synergistic TRAIL sensitizers

We have developed a high-throughput screen (HTS) to search for novel molecules that can synergize with TRAIL, thus promoting apoptosis of ACHN renal tumor cells in a combinatorial fashion. The HTS detects synthetic compounds and pure natural products that can pre-sensitize the cancer cells to TRAIL-...

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Detalhes bibliográficos
Main Authors: Booth, Nancy Lynn, Sayers, Thomas J., Brooks, Alan D., Thomas, Cheryl L., Jacobsen, Kristen, Goncharova, Ekaterina I., McMahon, James B., Henrich, Curtis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168559/
https://ncbi.nlm.nih.gov/pubmed/19089423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0637-8
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