Targeting genes for self-excision in the germ line

A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker...

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Bibliographic Details
Main Authors: Bunting, Michaeline, Bernstein, Kenneth E., Greer, Joy M., Capecchi, Mario R., Thomas, Kirk R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC316811/
https://ncbi.nlm.nih.gov/pubmed/10385621
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