Dickkopf1 Regulates Fate Decision and Drives Breast Cancer Stem Cells to Differentiation: An Experimentally Supported Mathematical Model

BACKGROUND: Modulation of cellular signaling pathways can change the replication/differentiation balance in cancer stem cells (CSCs), thus affecting tumor growth and recurrence. Analysis of a simple, experimentally verified, mathematical model suggests that this balance is maintained by quorum sensi...

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Detalhes bibliográficos
Main Authors: Agur, Zvia, Kirnasovsky, Oleg U., Vasserman, Genadiy, Tencer-Hershkowicz, Lilach, Kogan, Yuri, Harrison, Hannah, Lamb, Rebecca, Clarke, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167819/
https://ncbi.nlm.nih.gov/pubmed/21915302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024225
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