Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix–loop–helix repressor of neuronal differentiation

The induction of neurite outgrowth by NGF is a transcription-dependent process in PC12 cells, but the transcription factors that mediate this process are not known. Here we show that the bHLH transcriptional repressor HES-1 is a mediator of this process. Inactivation of endogenous HES-1 by forced ex...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Ström, Anders, Castella, Paul, Rockwood, Julia, Wagner, John, Caudy, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 1997
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9389649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.11.23.3168
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