Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines

The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required for optimal NF-κB activation, but little is known about the responsible substrate(s). Here we report that Malt1 cleaved the NF-κB family membe...

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Bibliographische Detailangaben
Hauptverfasser: Hailfinger, Stephan, Nogai, Hendrik, Pelzer, Christiane, Jaworski, Maike, Cabalzar, Katrin, Charton, Jean-Enno, Guzzardi, Montserrat, Décaillet, Chantal, Grau, Michael, Dörken, Bernd, Lenz, Peter, Lenz, Georg, Thome, Margot
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167514/
https://ncbi.nlm.nih.gov/pubmed/21873235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105020108
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