Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

In mice, the imprinted Igf2 gene (expressed from the paternal allele), which encodes a growth-promoting factor (IGF-II), is linked closely to the reciprocally imprinted H19 locus on chromosome 7. Also imprinted (expressed from the maternal allele) is the Igf2r gene on chromsome 17 encoding the type...

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Main Authors: Eggenschwiler, Jonathan, Ludwig, Thomas, Fisher, Peter, Leighton, Philip A., Tilghman, Shirley M., Efstratiadis, Argiris
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 1997
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC316748/
https://ncbi.nlm.nih.gov/pubmed/9389646
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