Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor pr...

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Main Authors: Nozawa, Hiroaki, Oda, Eri, Nakao, Kazuki, Ishihara, Masahiko, Ueda, Seiji, Yokochi, Taeko, Ogasawara, Kouetsu, Nakatsuru, Yoko, Shimizu, Seiichiro, Ohira, Yoshikazu, Hioki, Kyoji, Aizawa, Shinichi, Ishikawa, Takatoshi, Katsuki, Motoya, Muto, Tetsuichiro, Taniguchi, Tadatsugu, Tanaka, Nobuyuki
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1999
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC316726/
https://ncbi.nlm.nih.gov/pubmed/10346812
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