A Sphingosine Kinase Form 2 Knockout Sensitizes Mouse Myocardium to Ischemia/Reoxygenation Injury and Diminishes Responsiveness to Ischemic Preconditioning

Sphingosine kinase (SphK) exhibits two isoforms, SphK1 and SphK2. Both forms catalyze the synthesis of sphingosine 1-phosphate (S1P), a sphingolipid involved in ischemic preconditioning (IPC). Since the ratio of SphK1 : SphK2 changes dramatically with aging, it is important to assess the role of Sph...

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Autors principals: Vessey, Donald A., Li, Luyi, Jin, Zhu-Qiu, Kelley, Michael, Honbo, Norman, Zhang, Jianqing, Karliner, Joel S.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166792/
https://ncbi.nlm.nih.gov/pubmed/21904650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/961059
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