Regulation of cyclooxygenase-2 and cytosolic phospholipase A(2) gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases

BACKGROUND AND PURPOSE: Lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2) and cytosolic phospholipase A(2) (cPLA(2)) has been implicated in several respiratory diseases. HuR is known to enhance the expression of genes by binding to 3′-untranslated region (3′-UTR) of mRNA and st...

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Detalhes bibliográficos
Main Authors: Lin, Wei-Ning, Lin, Chih-Chung, Cheng, Hsin-Yi, Yang, Chuen-Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166696/
https://ncbi.nlm.nih.gov/pubmed/21391979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01312.x
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