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γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
β-Catenin and γ-catenin (plakoglobin), vertebrate homologs of Drosophila armadillo, function in cell adhesion and the Wnt signaling pathway. In colon and other cancers, mutations in the APC tumor suppressor protein or β-catenin's amino terminus stabilize β-catenin, enhancing its ability to acti...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2000
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316666/ https://ncbi.nlm.nih.gov/pubmed/10837025 |
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