Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties

We describe herein a new conformationally constrained analog of PNA carrying an alternating α/β amino acid backbone consisting of (2′R,4′R)-nucleobase-subtituted proline and (1S,2S)-2-aminocyclopentanecarboxylic acid (acpcPNA). The acpcPNA has been synthesized and evaluated for DNA, RNA and self-pai...

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Hauptverfasser: Vilaivan, Chotima, Srisuwannaket, Choladda, Ananthanawat, Cheeraporn, Suparpprom, Chaturong, Kawakami, Junji, Yamaguchi, Yoshie, Tanaka, Yuko, Vilaivan, Tirayut
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166490/
https://ncbi.nlm.nih.gov/pubmed/21912727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.2.2.16340
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