KIR and HLA-C Interactions Promote Differential Dendritic Cell Maturation and Is a Major Determinant of Graft Failure following Kidney Transplantation

BACKGROUND: HLA-C is an important ligand for killer immunoglobulin like receptors (KIR) that regulate natural killer (NK) cell function. Based on KIR specificity HLA-C molecules are allocated into two groups, HLA-C1 or HLA-C2; HLA-C2 is more inhibiting to NK cell function than HLA-C1. We studied the...

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Hauptverfasser: Hanvesakul, Raj, Kubal, Chandrashekhar, Moore, Jason, Neil, Desley, Cook, Mark, Ball, Simon, Briggs, David, Moss, Paul, Cockwell, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166139/
https://ncbi.nlm.nih.gov/pubmed/21912600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023631
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