Age-Dependent Decline in Mouse Lung Regeneration with Loss of Lung Fibroblast Clonogenicity and Increased Myofibroblastic Differentiation

While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX on physiology, morphometry, cell proliferation an...

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Detalhes bibliográficos
Main Authors: Paxson, Julia A., Gruntman, Alisha, Parkin, Christopher D., Mazan, Melissa R., Davis, Airiel, Ingenito, Edward P., Hoffman, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166052/
https://ncbi.nlm.nih.gov/pubmed/21912590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023232
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