Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65

Latency-associated nuclear antigen 1 (LANA-1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is the major viral latent protein and functions as a multifaceted protein. Here, we report that LANA-1 attenuates the endothelial response to tumor necrosis factor alpha (TNF-α) stimulation and inhib...

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Detalles Bibliográficos
Main Authors: Li, Xiaofan, Liang, Deguang, Lin, Xianzhi, Robertson, Erle S., Lan, Ke
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165807/
https://ncbi.nlm.nih.gov/pubmed/21697472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00733-11
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