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Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells

To interrogate endogenous p21(WAF1/CIP1) (p21) promoter activity under basal conditions and in response to various forms of stress, knock-in imaging reporter mice in which expression of firefly luciferase (FLuc) was placed under the control of the endogenous p21 promoter within the Cdkn1a gene locus...

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Bibliografski detalji
Glavni autori: Tinkum, Kelsey L., Marpegan, Luciano, White, Lynn S., Sun, Jinwu, Herzog, Erik D., Piwnica-Worms, David, Piwnica-Worms, Helen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165732/
https://ncbi.nlm.nih.gov/pubmed/21791610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05243-11
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