In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions

Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower...

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Detalhes bibliográficos
Main Authors: Stubbings, Will, Leow, Pamela, Yong, Goh Chee, Goh, Falicia, Körber-Irrgang, Barbara, Kresken, Michael, Endermann, Rainer, Labischinski, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165343/
https://ncbi.nlm.nih.gov/pubmed/21709094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00833-10
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