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A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Despite intense efforts over the past 30 years, human pancreatic β cell lines have not been available. Here, we describe a robust technology for producing a functional human β cell line using targeted oncogenesis in human fetal tissue. Human fetal pancreatic buds were transduced with a lentiviral ve...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163974/ https://ncbi.nlm.nih.gov/pubmed/21865645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58447 |
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