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Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice

Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important targets of genetic diseases. However, surprisingly little is known about the relat...

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Detalhes bibliográficos
Main Authors: Kraft, Michael, Cirstea, Ion Cristian, Voss, Anne Kathrin, Thomas, Tim, Goehring, Ina, Sheikh, Bilal N., Gordon, Lavinia, Scott, Hamish, Smyth, Gordon K., Ahmadian, Mohammad Reza, Trautmann, Udo, Zenker, Martin, Tartaglia, Marco, Ekici, Arif, Reis, André, Dörr, Helmuth-Guenther, Rauch, Anita, Thiel, Christian Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163944/
https://ncbi.nlm.nih.gov/pubmed/21804188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43428
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