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Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice
Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important targets of genetic diseases. However, surprisingly little is known about the relat...
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Главные авторы: | , , , , , , , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Clinical Investigation
2011
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163944/ https://ncbi.nlm.nih.gov/pubmed/21804188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43428 |
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