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Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice

Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important targets of genetic diseases. However, surprisingly little is known about the relat...

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Библиографические подробности
Главные авторы: Kraft, Michael, Cirstea, Ion Cristian, Voss, Anne Kathrin, Thomas, Tim, Goehring, Ina, Sheikh, Bilal N., Gordon, Lavinia, Scott, Hamish, Smyth, Gordon K., Ahmadian, Mohammad Reza, Trautmann, Udo, Zenker, Martin, Tartaglia, Marco, Ekici, Arif, Reis, André, Dörr, Helmuth-Guenther, Rauch, Anita, Thiel, Christian Thomas
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163944/
https://ncbi.nlm.nih.gov/pubmed/21804188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43428
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