Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium But Does Not Expand the Presumptive Stem Cell Pool

BACKGROUND & AIMS: Adenomatous polyps are precursors to colorectal cancer (CRC), whereas hyperplastic polyps (HPPs) have a small risk of progression to CRC. Mutations in KRAS are found in ~40% of CRCs and large adenomas and a subset of HPPs. We investigated the reasons that HPPs with KRAS mutati...

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Detalhes bibliográficos
Main Authors: Feng, Ying, Bommer, Guido T., Zhao, Jenny, Green, Maranne, Sands, Evan, Zhai, Yali, Brown, Kelly, Burberry, Aaron, Cho, Kathleen R., Fearon, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163826/
https://ncbi.nlm.nih.gov/pubmed/21699772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.05.007
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