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Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria

We have identified a mutant in RPB3, the third-largest subunit of yeast RNA polymerase II, that is defective in activator-dependent transcription, but not defective in activator-independent, basal transcription. The mutant contains two amino-acid substitutions, C92R and A159G, that are both required...

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Main Authors: Tan, Qian, Linask, K. Liisi, Ebright, Richard H., Woychik, Nancy A.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC316356/
https://ncbi.nlm.nih.gov/pubmed/10673505
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