Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

The switch to an angiogenic phenotype is a fundamental determinant of neoplastic growth and tumor progression. We demonstrate that homozygous deletion of the p53 tumor suppressor gene via homologous recombination in a human cancer cell line promotes the neovascularization and growth of tumor xenogra...

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Detalhes bibliográficos
Main Authors: Ravi, Rajani, Mookerjee, Bijoyesh, Bhujwalla, Zaver M., Sutter, Carrie Hayes, Artemov, Dmitri, Zeng, Qinwen, Dillehay, Larry E., Madan, Ashima, Semenza, Gregg L., Bedi, Atul
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2000
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316350/
https://ncbi.nlm.nih.gov/pubmed/10640274
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