Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

BACKGROUND: Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is limited by the lack of efficient intracellular delivery. In this study we evaluated whether electroporation cou...

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Bibliographic Details
Main Authors: Spugnini, Enrico P, Biroccio, Annamaria, De Mori, Roberta, Scarsella, Marco, D'Angelo, Carmen, Baldi, Alfonso, Leonetti, Carlo
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163203/
https://ncbi.nlm.nih.gov/pubmed/21798045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-125
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