The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance

We tested the hypothesis that TAG accumulation in the liver induced by short-term high-fat diet (HFD) in rats leads to the dysregulation of endogenous TAG degradation by lysosomal lipase (LIPA) via lysosomal pathway and is causally linked with the onset of hepatic insulin resistance. We found that L...

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Detalhes bibliográficos
Main Authors: Cahova, Monika, Dankova, Helena, Palenickova, Eliska, Papackova, Zuzana, Komers, Radko, Zdychova, Jana, Sticova, Eva, Kazdova, Ludmila
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163129/
https://ncbi.nlm.nih.gov/pubmed/21904679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/135723
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