Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than...

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Autors principals: Agrawal, Nishant, Frederick, Mitchell J., Pickering, Curtis R., Bettegowda, Chetan, Chang, Kyle, Li, Ryan J., Fakhry, Carole, Xie, Tong-Xin, Zhang, Jiexin, Wang, Jing, Zhang, Nianxiang, El-Naggar, Adel K., Jasser, Samar A., Weinstein, John N., Treviño, Lisa, Drummond, Jennifer A., Muzny, Donna M., Wu, Yuanqing, Wood, Laura D., Hruban, Ralph H., Westra, William H., Koch, Wayne M., Califano, Joseph A., Gibbs, Richard A., Sidransky, David, Vogelstein, Bert, Velculescu, Victor E., Papadopoulos, Nickolas, Wheeler, David A., Kinzler, Kenneth W., Myers, Jeffrey N.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162986/
https://ncbi.nlm.nih.gov/pubmed/21798897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1206923
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