Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers

AIMS: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine. Formation of 5-HMT from fesoterodine and tolterodine occurs via esterases and CYP2D6 respectively. This randomized, crossover, open-label, mul...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Malhotra, Bimal, Darsey, Edress, Crownover, Penelope, Fang, Juanzhi, Glue, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2011
Gaiak:
Uropharmacology Themed Section
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162652/
https://ncbi.nlm.nih.gov/pubmed/21352267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03948.x
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