Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers

AIMS: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine. Formation of 5-HMT from fesoterodine and tolterodine occurs via esterases and CYP2D6 respectively. This randomized, crossover, open-label, mul...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Malhotra, Bimal, Darsey, Edress, Crownover, Penelope, Fang, Juanzhi, Glue, Paul
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2011
Assuntos:
Uropharmacology Themed Section
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162652/
https://ncbi.nlm.nih.gov/pubmed/21352267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03948.x
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares