Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment

PURPOSE: For years, 5-fluorouracil (5-FU) has been the backbone of radiochemotherapy (RCT) of locally advanced rectal cancer. Its main target, thymidylate synthase (TS), is speculated to be an important biomarker for response prediction and long-term prognosis. In this study, we analyzed TS expressi...

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Detalhes bibliográficos
Main Authors: Conradi, Lena-Christin, Bleckmann, Annalen, Schirmer, Markus, Sprenger, Thilo, Jo, Peter, Homayounfar, Kia, Wolff, Hendrik A., Rothe, Hilka, Middel, Peter, Becker, Heinz, Ghadimi, Michael B., Beissbarth, Tim, Liersch, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
Assuntos:
Gastrointestinal Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162628/
https://ncbi.nlm.nih.gov/pubmed/21347782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-011-1608-4
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