Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

Lafora Disease (LD) is a fatal neurodegenerative epileptic disorder that presents as a neurological deterioration with the accumulation of insoluble, intracellular, hyperphosphorylated carbohydrates called Lafora bodies (LBs). LD is caused by mutations in either the gene encoding laforin or malin. L...

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Autori principali: Dukhande, Vikas V., Rogers, Devin M., Romá-Mateo, Carlos, Donderis, Jordi, Marina, Alberto, Taylor, Adam O., Sanz, Pascual, Gentry, Matthew S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162602/
https://ncbi.nlm.nih.gov/pubmed/21887368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024040
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