The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is a candidate gene for schizophrenia and an important drug target for cognitive deficits in the disorder. Activation of the α7*nAChR, results in opening of the channel and entry of mono- and divalent cations, including Ca(++), tha...

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Hlavní autoři: Araud, Tanguy, Graw, Sharon, Berger, Ralph, Lee, Michael, Neveu, Estelle, Bertrand, Daniel, Leonard, Sherry
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162115/
https://ncbi.nlm.nih.gov/pubmed/21718690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.06.018
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