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Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast

Aging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard strain RM11 and a laboratory strain S288c, to identify quantitative trait loci tha...

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Main Authors: Kwan, Elizabeth X., Foss, Eric, Kruglyak, Leonid, Bedalov, Antonio
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161923/
https://ncbi.nlm.nih.gov/pubmed/21901113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002250
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