Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival

INTRODUCTION: Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen...

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Bibliografiske detaljer
Main Authors: Andersen, Sigve, Donnem, Tom, Stenvold, Helge, Al-Saad, Samer, Al-Shibli, Khalid, Busund, Lill-Tove, Bremnes, Roy M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161788/
https://ncbi.nlm.nih.gov/pubmed/21887331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023847
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