Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

OBJECTIVE: Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to p...

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Bibliographic Details
Main Authors: Cabou, Cendrine, Vachoux, Christelle, Campistron, Gérard, Drucker, Daniel J., Burcelin, Rémy
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161335/
https://ncbi.nlm.nih.gov/pubmed/21810595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0464
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