GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy

Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression. Multiple linkage and population association studies have connected the bromodomain-containing gene BRD2 to forms of IGE. In mi...

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Autori principali: Velíšek, Libor, Shang, Enyuan, Velíšková, Jana, Chachua, Tamar, Macchiarulo, Stephania, Maglakelidze, Giorgi, Wolgemuth, Debra J., Greenberg, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161054/
https://ncbi.nlm.nih.gov/pubmed/21887291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023656
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