The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome

BACKGROUND: Rett syndrome is a neurodevelopmental and autistic disease caused by mutations of Methyl-CpG-binding protein 2 (MECP2) gene. MeCP2 protein is mainly expressed in neurons and binds to methylated gene promoters to suppress their expression, indicating that Rett syndrome is caused by the de...

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Détails bibliographiques
Auteurs principaux: Miyake, Kunio, Hirasawa, Takae, Soutome, Masaki, Itoh, Masayuki, Goto, Yu-ichi, Endoh, Kazushi, Takahashi, Kenichiro, Kudo, Shinichi, Nakagawa, Takayuki, Yokoi, Sana, Taira, Takahiro, Inazawa, Johji, Kubota, Takeo
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160964/
https://ncbi.nlm.nih.gov/pubmed/21824415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-81
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