Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo

OBJECTIVE: To deliver 2,3,5,6-tetramethylpyrazine (TMP) in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. METHODS: The pseudo-ternary phase diagram for microemulsion regions was constructed using isopropyl m...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Ji-Hui, Ji, Li, Wang, Hui, Chen, Zhi-Qiang, Zhang, Yong-Tai, Liu, Ying, Feng, Nian-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2011
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160947/
https://ncbi.nlm.nih.gov/pubmed/21904451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S23597
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