Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

Correct replication of the genome and protection of its integrity are essential for cell survival. In a high-throughput screen studying H2AX phosphorylation, we identified Wee1 as a regulator of genomic stability. Wee1 down-regulation not only induced H2AX phosphorylation but also triggered a genera...

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Bibliografiska uppgifter
Huvudupphovsmän: Domínguez-Kelly, Raquel, Martín, Yusé, Koundrioukoff, Stephane, Tanenbaum, Marvin E., Smits, Veronique A.J., Medema, René H., Debatisse, Michelle, Freire, Raimundo
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2011
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160579/
https://ncbi.nlm.nih.gov/pubmed/21859861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201101047
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