Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA...

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Detalles Bibliográficos
Main Authors: Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2011
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Original Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160204/
https://ncbi.nlm.nih.gov/pubmed/21693554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881111405366
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