Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA...

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Detalhes bibliográficos
Main Authors: Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2011
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160204/
https://ncbi.nlm.nih.gov/pubmed/21693554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881111405366
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