Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2011
Sujets:
Original Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160204/
https://ncbi.nlm.nih.gov/pubmed/21693554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881111405366
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