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Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry

Cilia at the node generate a leftward fluid flow that breaks left-right symmetry. However, the molecular mechanisms that regulate ciliogenesis at the node are largely unknown. Here, we show that the epiblast-specific deletion of the gene encoding the BMP type 1 receptor (Acvr1) compromised developme...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Komatsu, Yoshihiro, Kaartinen, Vesa, Mishina, Yuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160088/
https://ncbi.nlm.nih.gov/pubmed/21831921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.068833
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