P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)

BACKGROUND: Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertake...

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Hauptverfasser: Walts, Ann E., Lechago, Juan, Hu, Bing, Shwayder, MaryBeth, Sandweiss, Lynn, Bose, Shikha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Libertas Academica 2008
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159996/
https://ncbi.nlm.nih.gov/pubmed/21876646
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