Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a profound loss of life quality and premature death. Around 10% of the cases are inherited and ALS8 is an autosomal dominant form of familial ALS caused by mutations in the vamp-associated protein B/C (VAPB) gene...

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Hlavní autoři: Mitne-Neto, Miguel, Machado-Costa, Marcela, Marchetto, Maria C.N., Bengtson, Mario H., Joazeiro, Claudio A., Tsuda, Hiroshi, Bellen, Hugo J., Silva, Helga C.A., Oliveira, Acary S.B., Lazar, Monize, Muotri, Alysson R., Zatz, Mayana
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159551/
https://ncbi.nlm.nih.gov/pubmed/21685205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr284
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