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Native homing endonucleases can target conserved genes in humans and in animal models
In recent years, both homing endonucleases (HEases) and zinc-finger nucleases (ZFNs) have been engineered and selected for the targeting of desired human loci for gene therapy. However, enzyme engineering is lengthy and expensive and the off-target effect of the manufactured endonucleases is difficu...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159444/ https://ncbi.nlm.nih.gov/pubmed/21525128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr242 |
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