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Glycan Shielding of the Influenza Virus Hemagglutinin Contributes to Immunopathology in Mice

Rationale: Pandemic influenza viruses historically have had few potential sites for N-linked glycosylation on the globular head of the hemagglutinin (HA) on emergence from the avian reservoir. Gain of glycans within antigenic sites of the HA during adaptation to the mammalian lung facilitates immune...

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Bibliografske podrobnosti
Main Authors: Wanzeck, Keith, Boyd, Kelli L., McCullers, Jonathan A.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159075/
https://ncbi.nlm.nih.gov/pubmed/20935106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201007-1184OC
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